Skip to main content
Trimix FAQ's

Frequently asked questions about trimix: its uses, side effects, and limitations.

Updated over 5 months ago

Is the medication Trimix the same as Viagra?

No, Trimix is not the same as Viagra. Viagra (sildenafil) is a prescription medication that is used to treat erectile dysfunction (ED) by increasing blood flow to the penis. On the other hand, Trimix is a combination of three active ingredients (alprostadil, papaverine, and phentolamine) injected directly into the penis to treat ED. While both medications are used to treat ED, they have different ingredients, mechanisms of action, and administration methods.

How long do Trimix injections last?

The duration of Trimix injections can vary, but typically they last for 30 minutes to several hours. Factors such as age, overall health, dose, and frequency of use can affect the duration of the injections.

How much does a bottle of Trimix cost?

The cost of a bottle of Trimix can vary depending on several factors, such as the size of the bottle, the dose of medication, and the location of purchase.

What are the dangers of using Trimix?

Trimix can be an effective treatment for erectile dysfunction (ED). However, if used incorrectly, it can also have potential side effects and dangers. Some of the common side effects of Trimix include

  • Pain or swelling at the injection site

  • Priapism (prolonged and painful erections)

  • Blood in the urine

  • Fainting or dizziness

  • Nausea or vomiting etc.

In rare cases, Trimix injections can cause serious side effects such as heart attack, stroke, and sudden death. It's important to use Trimix only as directed by a healthcare provider and to stop using the medication and seek medical attention if you experience any serious side effects.

Can I use Trimix daily?

A healthcare provider should decide how often to use it based on the person's needs and health conditions. In general, Trimix is not recommended for daily use.

Using Trimix daily can increase the risk of side effects and complications. Prolonged and frequent use of Trimix can also lead to the development of penile scarring, which can make it difficult to achieve and maintain an erection in the future.

It's important to follow your doctor's instructions about how often and for how long to use Trimix. They will consider factors such as your overall health, the severity of your ED, and any other medications you are taking before determining a treatment plan that is safe and effective for you.

Can Viagra be used with Trimix?

It is not typically recommended. Using two medications with similar effects at the same time can increase the risk of side effects and complications.

Additionally, both Viagra and Trimix can cause low blood pressure, and combining the two medications can further lower blood pressure and increase the risk of dizziness or fainting.

Taking Viagra and Trimix together can also increase the risk of priapism, a prolonged, painful erection that can cause damage to the internal structure of the penis if it is left untreated.

Where do I inject Trimix?

Trimix is a prescription medication used to treat erectile dysfunction (ED) that is administered as an injection into the penis. The injection is usually given into the side of the penis, midway down the shaft.

What is the success rate of Trimix?

The success rate of Trimix can vary depending on several factors, such as the patient's medical history, the severity of their erectile dysfunction (ED), and their response to the medication. In clinical trials and studies, Trimix has been shown to be effective in treating ED in many patients.

However, the exact success rate of Trimix can vary and may not be the same for everyone. It's important to remember that ED is a complex condition with multiple causes, and the success of any treatment, including Trimix, will depend on the individual and the underlying cause of their ED. Studies have shown that Trimix is over 95% effective in treating ED, and 70% of men are very satisfied with using injectable ED medications

How many units of Trimix should I inject?

The correct dose of Trimix will vary depending on the patient and the severity of their erectile dysfunction (ED). A healthcare provider typically determines the appropriate dose of Trimix through trial and error, and the dose may be adjusted over time as needed. The starting dose of Trimix is usually between 5 and 15 units, but the exact dose will depend on several factors, such as the overall health of the patient, the severity of ED, and the patient's response to the medication.

How long does it take for Trimix to wear off?

The length of time that Trimix lasts can vary depending on several factors, such as the dose of the medication, the patient's overall health, and their response to the medication. The onset of action of Trimix typically occurs within 5 to 15 minutes after the injection is given, and the effects of the medication can last for 30 minutes to several hours.

Does Trimix affect your heart?

In general, Trimix is considered safe when used as directed. However, as with any medication, there are potential side effects and risks associated with its use. One of the potential side effects of Trimix is cardiovascular effects, such as changes in heart rate, rhythm, blood pressure, and blood flow.

What are the components of Trimix?

Trimix contains three active ingredients: alprostadil, a synthetic form of prostaglandin E1; papaverine, a smooth muscle relaxant; and phentolamine, an alpha-adrenergic blocker.

How effective are Alprostadil injections?

Alprostadil injections are a form of treatment for erectile dysfunction (ED) and are typically considered to be effective for many men with ED. According to several studies, the efficacy of alprostadil injections to treat erectile dysfunction can be as high as 80-90%.

However, the effectiveness of alprostadil injections may vary from person to person and can depend on several factors, such as the underlying cause of the ED, the individual's overall health, and their response to the medication.

Is Alprostadil injection safe?

Alprostadil is generally considered safe when used as directed. However, as with any medication, there are potential side effects and risks associated with its use.

Common side effects of alprostadil injections include pain, swelling, or redness at the injection site, as well as headaches, flushing, and a runny or stuffy nose.

In rare cases, alprostadil injections can cause more serious side effects, such as priapism (prolonged and painful erections), fibrosis (scarring) of the penis, and urethral bleeding.

Who should not take Alprostadil?

Some individuals may not be able to take alprostadil or may need to take it with caution due to certain medical conditions or other factors.

People who should not take alprostadil or use it with caution include people with a history of:

  • priapism (prolonged and painful erections)

  • bleeding disorders or who are taking blood-thinning medications, as alprostadil may increase the risk of bleeding

  • penile fibrosis (scarring) or Peyronie's disease

  • urethral stricture (narrowing of the urethra)

  • low blood pressure or heart problems, as alprostadil may affect blood pressure and heart rate

  • allergies to any of the components of alprostadil.

What kind of drug is phentolamine?

Phentolamine is a non-selective alpha-adrenergic blocker, which means it blocks the action of the hormone adrenaline at alpha-adrenergic receptors. It is primarily used as a vasodilator.

What are the contraindications of phentolamine?

There are some conditions that may be contraindicated or otherwise make the use of phentolamine potentially hazardous. These include cardiac conditions such as tachyarrhythmias or heart failure, hypotension, and allergic reactions.

How does phentolamine affect the heart?

Phentolamine is a non-selective alpha-adrenergic blocking agent, which means it blocks the effects of the hormone adrenaline on the heart. When adrenaline binds to alpha-adrenergic receptors on the heart, it increases the heart rate and the strength of heart contractions.

By blocking these receptors, phentolamine reduces the effects of adrenaline on the heart and thus can slow down the heart rate and reduce the strength of heart contractions.

What is the mechanism of action of papaverine?

Papaverine is a smooth muscle relaxant that works by inhibiting the action of certain enzymes responsible for contracting the smooth muscle cells.

The exact mechanism by which papaverine achieves this effect is not well understood, but it is thought to involve the inhibition of phosphodiesterase enzymes, which play a role in the breakdown of cyclic adenosine monophosphate (cAMP).

By inhibiting the breakdown of cAMP, papaverine increases the levels of cAMP within the smooth muscle cells, leading to smooth muscle relaxation.

What are the side effects of papaverine?

Papaverine can cause a variety of side effects, some of which are mild and temporary, while others can be more serious. Some of the common side effects of papaverine include:

  • nausea and vomiting

  • drowsiness or fatigue

  • headache

  • flushing of the skin

  • low blood pressure (hypotension)

  • constipation

  • blurred vision, etc.

Less common side effects of papaverine can include allergic reactions, such as itching, rashes, or hives, rapid or irregular heartbeat (tachycardia), chest pain or tightness, seizures, etc.

Does Trimix work without arousal?

Trimix is a combination of three medications that are used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis, which leads to an erection. To have an erection with Trimix, sexual arousal is not necessary.

What causes Trimix not to work?

There can be several reasons why Trimix may not work for some people with erectile dysfunction (ED). Some of the common reasons include:

  • dosage (If the dose is too low, it may not be effective in producing an erection)

  • prolonged use (over time, the effectiveness of Trimix may decrease due to the development of tolerance)

  • interactions with other medications

  • underlying health conditions: diabetes or cardiovascular disease

How many times a week can I use Trimix?

The frequency of use of Trimix, a mixture of alprostadil, papaverine, and phentolamine used to treat erectile dysfunction, is determined by a healthcare provider and varies from person to person. Do not use more than one injection in a 24-hour period.

How effective is alprostadil?

Alprostadil is a medication that is used to treat erectile dysfunction and is generally considered to be effective in helping many men achieve and maintain an erection. According to studies and clinical trials, between 60 and 80% of men who use alprostadil experience improvements in their ability to achieve and maintain an erection.

Is Alprostadil painful?

Pain is a possible side effect of alprostadil use. Some men may experience pain or a burning sensation at the injection site when using a Trimix injection. However, alprostadil dosages are lower in Trimix than they are when using alprostadil alone, which reduces side effects.

What drug class is alprostadil?

Alprostadil is a drug that belongs to the class of medications called prostaglandins. Specifically, it is a synthetic form of prostaglandin E1.

Is phentolamine a vasodilator?

Yes, phentolamine is a vasodilator drug. Phentolamine is an alpha-adrenergic blocker, which means it blocks the effects of the neurotransmitter norepinephrine.

Why does phentolamine reduce blood pressure?

Phentolamine lowers blood pressure by blocking the effects of norepinephrine, a neurotransmitter that narrows blood vessels.

When norepinephrine binds to alpha-adrenergic receptors on smooth muscle cells in blood vessels, it causes the muscles to contract. This causes the blood vessels to narrow and the blood pressure to rise.

Phentolamine blocks the binding of norepinephrine to these receptors, leading to the relaxation of the smooth muscle cells and dilation of the blood vessels, which reduces blood pressure.

Does phentolamine cause bradycardia?

Yes, phentolamine can cause bradycardia, which is a slowing of the heart rate. Phentolamine blocks the effects of the neurotransmitter norepinephrine, which acts as a stimulant to the heart. By blocking the action of norepinephrine, phentolamine can reduce the heart rate and lead to bradycardia.

Is phentolamine used for erectile dysfunction?

Because of how it works, phentolamine has been used in combination with other drugs like papaverine or alprostadil to treat erectile dysfunction.

How long does phentolamine last?

The exact length of time a drug works depends on things like a person's age, weight, medical history, and other drugs they are taking. It is important to follow the dosing instructions provided by a healthcare provider when taking phentolamine.

How long does Trimix keep you hard?

The length of time that Trimix can keep you hard depends on several factors, including the dose and the individual's response to the medication. In general, the effects of Trimix can last for up to one hour after it is injected into the penis.

What happens if you inject Trimix too often?

Injecting Trimix too often can lead to several adverse effects, including

  • Priapism: This is a persistent and painful erection that lasts for more than four hours and is not associated with sexual arousal. Priapism can cause damage to the erectile tissue and potentially lead to erectile dysfunction.

  • Penile fibrosis: Injecting Trimix too often can cause fibrous tissue to develop in the penis, leading to a decrease in penile elasticity and a reduction in the ability to attain and maintain an erection.

  • Pain or discomfort: Injecting Trimix too often can cause pain or discomfort in the penis.

  • Hematoma: Repeated injections can lead to the formation of a hematoma, which is a collection of blood outside of a blood vessel.

  • Allergic reactions: In rare cases, injecting Trimix can cause an allergic reaction, which can lead to redness, swelling, itching, or difficulty breathing.

Does Trimix work better than Viagra?

The effectiveness of Trimix and Viagra can vary from person to person and depend on things like the cause of erectile dysfunction, the person's overall health, and other medications they are taking.

Some people may find that Trimix is more effective for them, while others may find that Viagra works better. It is important to discuss the options with a healthcare provider to determine the best course of treatment.

What is stronger than Trimix?

Trimix is a strong medication used to treat erectile dysfunction, but there are other treatments that can be considered for individuals who have not responded well to Trimix.

Some of these treatments include

  • Penile implants

  • Testosterone replacement therapy

  • Vacuum erection devices

  • Penile injections with high-dose alprostadil

How much is a Trimix injection?

The cost of Trimix injections can vary depending on several factors, including the location, the pharmacy, and the insurance coverage.

Why is Trimix not working?

Trimix is a medication used to treat erectile dysfunction, but in some cases, it may not work effectively. There are several potential reasons why Trimix may not be working, including

  • Dosing: Trimix is a medication that is injected into the penis, and the dose may need to be adjusted for optimal effectiveness. If the dose is too low, Trimix may not produce the desired effect.

  • Medical conditions: Certain medical conditions, such as heart disease, diabetes, or high blood pressure, can contribute to erectile dysfunction and affect the effectiveness of Trimix.

  • Interactions with other medications: Trimix can interact with other medications, including anti-inflammatory drugs, blood pressure medications, and anti-depressants, which can affect its effectiveness.

  • Penile anatomic issues: Certain anatomic issues, such as Peyronie's disease, can affect the ability of Trimix to produce an erection.

  • Psychological factors: Psychological factors, such as anxiety or depression, can also contribute to erectile dysfunction and affect the effectiveness of Trimix.

Does Trimix come in a pill?

No, Trimix is not available in pill form. It comes in a liquid form and is injected with a small needle into the penis.

How do you inject yourself with Trimix?

It is important to follow the instructions provided by a healthcare provider for the proper administration of Trimix injections. In general, the following steps should be followed:

  • Clean the injection site: Clean the injection site with soap and water and let it dry completely.

  • Assemble the needle and syringe: Open the packaging and carefully remove the needle and syringe. Make sure the needle is sterile and undamaged.

  • Draw up the medication: Remove the needle cap and attach it to the syringe. Turn the bottle of Trimix upside down and insert the needle into the bottle. Draw the prescribed amount of Trimix into the syringe.

  • Inject the medication.

  • Dispose of the needle and syringe: After the injection, remove the needle from the penis and dispose of it properly in a sharps container.

Where is the best place to inject Trimix?

The best place to inject Trimix is into the shaft of the penis. The shaft is the part of the penis that is located between the base and the head.

The injection site should be cleansed with soap and water, and a small amount of tissue should be pinched at the injection site to create a raised area. The needle should be inserted into the raised area at a 45-degree angle, and the medication should be slowly injected.

Should Trimix be injected slowly?

Yes, Trimix should be injected slowly. Injecting Trimix too quickly can increase the risk of side effects and discomfort. Trimix is usually injected over a period of several seconds, allowing the medication to be absorbed into the blood vessels. The injection should be slow and steady, without jerking or moving the needle.

What angle do you inject Trimix?

In general, injections are usually given at a 90-degree angle or a 45-degree angle, using a needle that is long enough to reach the target tissue.

How long do I keep Trimix in a syringe?

The shelf life of Trimix in a syringe depends on several factors, including the composition of the solution, storage conditions, and the presence of bacteria or other contaminants. Generally, Trimix should be used within 24 hours of being drawn up into a syringe and should be discarded if there is any discoloration or particulate matter in the solution.

How long does Trimix last?

The duration of the effect of Trimix varies depending on several factors, including the dose, the individual's response, and the specific medical condition being treated.

In general, Trimix is used to treat erectile dysfunction and can produce an erection within 5 to 20 minutes of injection, and the effect can last for up to an hour or more.

How long does Trimix last after opening?

Generally, Trimix should be used by the best used by date on the vial and should be discarded if there is any discoloration or particulate matter in the solution. It is important to store Trimix at room temperature and to protect it from light, as exposure to light and high temperatures can degrade the solution. Additionally, it is important to use an aseptic technique when preparing and administering Trimix to minimize the risk of infection.

How big is the needle for Trimix?

In general, a 22- to 27-gauge needle is typically used for intracavernosal injections, such as those used to treat erectile dysfunction. The length of the needle can also vary, but a needle length of 1 inch to 1.5 inches is commonly used.

Do you need stimulation for Trimix to work?

Trimix, a medication used to treat erectile dysfunction (ED), does not require stimulation to produce an erection. The medication works by increasing blood flow to the penis, which allows for the development of an erection.

Does Trimix lose potency?

Trimix can lose potency over time. The shelf life of Trimix depends on several factors, including the composition of the solution, storage conditions, and the presence of bacteria or other contaminants.

Exposure to light, high temperatures, and air can cause the active ingredients in Trimix to break down and lose potency, so it is important to store the medication properly and use an aseptic technique when preparing and administering the injection.

Once Trimix is drawn into a syringe, it should be used within 24 hours to ensure that the medication remains potent. If there is any discoloration or particulate matter in the solution, the Trimix should be discarded.

Can I use expired Trimix?

No, you should not use expired Trimix. The potency of the medication can deteriorate over time, particularly if it is stored improperly or exposed to light, heat, or air. Using expired Trimix could result in reduced efficacy or increased adverse side effects.

Will trimix work if not refrigerated?

The vial of Trimix that you are currently using should be stored in the refrigerator. All other vials should be kept in the freezer. Trimix can be left at room temperature for a short period while you are using it. While traveling, transport Trimix with an ice pack.

Did this answer your question?